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Omar S. Mabrouk, Daniel Z. Semaan, Sarah Mikelman, Margaret E. Gnegy and Robert T. Kennedy Amphetamine stimulates movement through thalamocortical glutamate release Journal of Neurochemistry 128

Article first published online: 19 AUG 2013 | DOI: 10.1111/jnc.12378

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This study utilizes dual probe microdialysis sampling and comprehensive LC-MS analysis to determine the effects of amphetamine (1 mg/kg i.p.) on thalamocortical neurotransmission. Using pharmacological tools such as local thalamic tetrodotoxin (TTX) perfusion and glutamate antagonist at the cortical level, we demonstrate that thalamocortical glutamate (acting primarily through cortical AMPA receptors) is an essential component in amphetamine-induced hyperlocomotion.

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