Sally-Ann Hobson, Penny A. Vanderplank, Robert J. P. Pope, Niall C. H. Kerr and David Wynick Galanin stimulates neurite outgrowth from sensory neurons by inhibition of Cdc42 and Rho GTPases and activation of cofilin Journal of Neurochemistry 127
Galanin plays a key role in neurite outgrowth from adult sensory neurons via activation of the second galanin receptor (GalR2). Our results demonstrate the galanin decreases the activation state of Rho and Cdc42 and markedly increases the activation of cofilin. These changes lead to alterations in growth cone motility. These findings have important implications for the treatment of peripheral sensory neuropathies.
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