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Deepak K. Kaushik, Menaka C. Thounaojam, Kanhaiya L. Kumawat, Malvika Gupta and Anirban Basu Interleukin-1β orchestrates underlying inflammatory responses in microglia via Krüppel-like factor 4 Journal of Neurochemistry 127

Version of Record online: 19 AUG 2013 | DOI: 10.1111/jnc.12382

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IL-1β is a potent pro-inflammatory cytokine which regulates inflammation in brain via activation of microglia. In this regard, we unravelled mechanisms for IL-1β mediated regulation of downstream Cox-2, iNOS (inducible nitric oxide synthase) as well as other cyto-chemokines in microglia and have established a role for Klf4 in mediating microglial activation. We further report that Klf4 mediates the production of endogenous IL-1β in response to exogenous IL-1β stimulation. We hereby propose a novel transcription factor underlying IL-1β mediated modulation of inflammation in the CNS.

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