Khalil Saadipour, Miao Yang, Yoon Lim, Kristen Georgiou, Ying Sun, Damien Keating, Jia Liu, Ye-Ran Wang, Wei-ping Gai, Jin-hua Zhong, Yan-Jiang Wang and Xin-Fu Zhou Amyloid beta1–42 (Aβ42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway Journal of Neurochemistry 127
Sortilin is the co-receptor of p75NTR which signals the cell death induced by Aβ and proneurotrophins. We found that sortilin is increased in the AD brain and up-regulated by Aβ and pro-brain-derived neurotrophic factor (proBDNF). Aβ-induced upregulation of sortilin is mediated by p75NTR and the down-streaming RhoA-ROCK signaling pathway. The Aβ/Sortilinp/75NTR signaling may play a role in the pathogenesis of AD.
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