E-mail a Wiley Online Library Link

Eirini-Maria Georganta, Lambrini Tsoutsi, Maria Gaitanou and Zafiroula Georgoussi δ-opioid receptor activation leads to neurite outgrowth and neuronal differentiation via a STAT5B-Gαi/o pathway Journal of Neurochemistry 127

Version of Record online: 18 SEP 2013 | DOI: 10.1111/jnc.12386

Thumbnail image of graphical abstract

We propose a novel signalling pathway for δ-opioid receptor (δ-ΟR)-mediated neurotropic events. STAT5B interacts with the δ-ΟR and upon prolonged receptor activation phosphorylates STAT5B in a Gi/Go dependent manner leading to increased neuronal survival, neurite outgrowth and differentiation. These findings contribute to a better understanding of the molecular and cellular events following δ-OR activation and suggest a possible neuroprotective role opioids could exert.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field