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Eirini-Maria Georganta, Lambrini Tsoutsi, Maria Gaitanou and Zafiroula Georgoussi δ-opioid receptor activation leads to neurite outgrowth and neuronal differentiation via a STAT5B-Gαi/o pathway Journal of Neurochemistry 127

Version of Record online: 18 SEP 2013 | DOI: 10.1111/jnc.12386

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We propose a novel signalling pathway for δ-opioid receptor (δ-ΟR)-mediated neurotropic events. STAT5B interacts with the δ-ΟR and upon prolonged receptor activation phosphorylates STAT5B in a Gi/Go dependent manner leading to increased neuronal survival, neurite outgrowth and differentiation. These findings contribute to a better understanding of the molecular and cellular events following δ-OR activation and suggest a possible neuroprotective role opioids could exert.

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