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Sarah K. Orr, Sara Palumbo, Francesca Bosetti, Howard T. Mount, Jing X. Kang, Carol E. Greenwood, David W. L. Ma, Charles N. Serhan and Richard P. Bazinet Unesterified docosahexaenoic acid is protective in neuroinflammation Journal of Neurochemistry 127

Version of Record online: 28 AUG 2013 | DOI: 10.1111/jnc.12392

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Our study shows that chronically increased brain unesterified DHA levels, but not solely phospholipid DHA levels, attenuate neuroinflammation. Similar attenuations occur with acute increases in brain unesterified DHA or 17S-HpDHA levels, highlighting the importance of an available pool of precursor unesterified DHA for the production of enzymatically derived specialized pro-resolving mediators that are critical in the regulation of neuroinflammation.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12439.

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