Narinobu Juge, Hiroshi Omote and Yoshinori Moriyama Vesicular GABA transporter (VGAT) transports β-alanine Journal of Neurochemistry 127
Vesicular GABA transporter (VGAT) is expressed in GABAergic and glycinergic neurons, and is responsible for vesicular storage and subsequent exocytosis of these inhibitory amino acids. In the present study, we showed that proteoliposomes containing purified VGAT transport β-alanine using Δψ as a driving force. VGAT also facilitates Cl− uptake. Our findings indicated that VGAT functions as a vesicular β-alanine transporter.
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