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Narinobu Juge, Hiroshi Omote and Yoshinori Moriyama Vesicular GABA transporter (VGAT) transports β-alanine Journal of Neurochemistry 127

Version of Record online: 26 AUG 2013 | DOI: 10.1111/jnc.12393

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Vesicular GABA transporter (VGAT) is expressed in GABAergic and glycinergic neurons, and is responsible for vesicular storage and subsequent exocytosis of these inhibitory amino acids. In the present study, we showed that proteoliposomes containing purified VGAT transport β-alanine using Δψ as a driving force. VGAT also facilitates Cl uptake. Our findings indicated that VGAT functions as a vesicular β-alanine transporter.

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