Lezi E, Jianghua Lu, J. Eva Selfridge, Jeffrey M. Burns and Russell H. Swerdlow Lactate administration reproduces specific brain and liver exercise-related changes Journal of Neurochemistry 127
In mice, exercise induces liver peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) mRNA, increases gluconeogenesis, but otherwise minimally affects respiration infrastructure. Brain PGC-1-related co-activator (PRC) mRNA, mitochondrial DNA (mtDNA), and vascular endothelial growth factor A (VEGF-A) mRNA increase, whereas tumor necrosis factor alpha (TNF-α) mRNA decreases. Lactate injection reproduces some, but not all, of these effects. Exercise-generated lactate, therefore, likely mediates some exercise-associated liver and brain effects.
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