David A. Davis, Garnik Akopian, John P. Walsh, Constantinos Sioutas, Todd E. Morgan and Caleb E. Finch Urban air pollutants reduce synaptic function of CA1 neurons via an NMDA/NȮ pathway in vitro Journal of Neurochemistry 127
We present three new findings of rapid hippocampal slice responses to nPM (nano-sized particulate matter from urban traffic): increased NȮ production within 15 min; nitrosylation of glutamatergic NMDA receptors; and, reduced excitatory postsynaptic currents in CA1 neurons. AP5 (NMDA receptor antagonist) blocked nPM-mediated NȮ and receptor nitrosylation. Ca2+ influx is a likely mechanism.
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