Yao-Chang Chiang, Yan-Ni Lo and Jin-Chung Chen Crosstalk between Dopamine D2 receptors and cannabinoid CB1 receptors regulates CNR1 promoter activity via ERK1/2 signaling Journal of Neurochemistry 127
Cannabinoid CB1R and dopamine D2R cross-talk at ERK1/2 signal. Activation of D2SR increases the CB1R transcription, which is ERK1/2 dependent and enhances CB1R promoter activity that requires up-stream −1 to −222 region. The results implicate pre-synaptic D2SR could functionally regulate the retrograde cannabinoid signal in the striatum.
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