Suman Jayadev, Amanda Case, Betty Alajajian, Alison J. Eastman, Thomas Möller and Gwenn A. Garden Presenilin 2 influences miR146 level and activity in microglia Journal of Neurochemistry 127
Presenilin 2 (PS2), a membrane associated protease, has been implicated in the pathogenesis of Alzheimer disease. We have previously shown that PS2 plays an important role in curbing the proinflammatory response in microglia. Here, we report the novel finding that PS2 participates in maintaining the basal and cytokine induced expression of the innate immunity regulating microRNA, miR146. These data suggest one mechanism by which PS2 works to reign in proinflammatory microglial behavior and that PS2 dysfunction or deficiency could thus result in unchecked proinflammatory activation contributing to neurodegeneration.
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