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Dao-Zhong Jin, Ming-Lei Guo, Bing Xue, Li-Min Mao and John Q. Wang Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca2+ in neurons Journal of Neurochemistry 127

Article first published online: 17 SEP 2013 | DOI: 10.1111/jnc.12434

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We show that activation of mGluR5 with a selective agonist triggers intracellular Ca2+ release in striatal neurons. Released Ca2+ dissociates preformed CaMKIIα from mGluR5 and meanwhile promotes active CaMKIIα to bind to the adjacent NMDAR GluN2B subunit, which enables CaMKIIα to phosphorylate GluN2B at a CaMKIIα-sensitive site. This agonist-induced cascade seems to mediate crosstalk between mGluR5 and NMDA receptors in neurons.

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