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Uzay E. Emir, Howard Brent Clark, Manda L. Vollmers, Lynn E. Eberly and Gülin Öz Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1 Journal of Neurochemistry 127

Version of Record online: 17 SEP 2013 | DOI: 10.1111/jnc.12435

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We measured cerebellar neurochemical alterations in a knock-in mouse model of spinocerebellar ataxia type 1, a hereditary movement disorder, using ultra-high field magnetic resonance spectroscopy (MRS). Very early neurochemical alterations were detectable prior to overt pathology in the volume-of-interest for MRS. Alterations were indicative of osmolytic changes and of disturbances in membrane phospholipid and energy metabolism.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12448.

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