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Eric D. Gaier, Megan B. Miller, Martina Ralle, Dipendra Aryal, William C. Wetsel, Richard E. Mains and Betty A. Eipper Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity Journal of Neurochemistry 127

Version of Record online: 13 OCT 2013 | DOI: 10.1111/jnc.12438

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Atp7a, a Cu-transporting P-type ATPase, is localized to the trans-Golgi network and to vesicles distributed throughout the dendritic arbor. Tissue-specific alterations in Atp7a expression were found in mice heterozygous for peptidylglycine α-amidating monooxygenase (PAM), an essential neuropeptide-synthesizing cuproenzyme. Atp7a and PAM are highly expressed in amygdalar interneurons. Reduced amygdalar expression of Atox-1 and Atp7a in PAM heterozygous mice may lead to reduced synaptic Cu levels, contributing to the behavioral and neurochemical alterations seen in these mice.

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