Mikayala D. A. King, Gareth W. Phillips, Paola A. Bignone, Nandini V. L. Hayes, Jennifer C. Pinder and Anthony J. Baines A conserved sequence in calmodulin regulated spectrin-associated protein 1 links its interaction with spectrin and calmodulin to neurite outgrowth Journal of Neurochemistry 128
Knockdown of the cytoskeletal protein CAMSAP1 using siRNA inhibited NGF-induced (nerve growth factor) neurite outgrowth from PC12 cells, and axon production by cerebellar granule cells in culture. This activity is linked to a spectrin- and Ca2+/calmodulin-binding region (CC1), since over-expression of isolated CC1 inhibited neurite production from PC12 cells. We previously showed that CAMSAP1 binds microtubules at the C-terminal CKK domain. Our data indicates CAMSAP1 is a cytoskeletal interconnector required for neurite and axon production.
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