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George R. Flentke, Ana Garic, Marcos Hernandez and Susan M. Smith CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin Journal of Neurochemistry 128

Version of Record online: 24 OCT 2013 | DOI: 10.1111/jnc.12464

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We proposed that ethanol initiates apoptosis in early neuroprogenitors through an intracellular calcium transient that activates CaMKII, which in turn destabilizes transcriptionally-active beta-catenin, perhaps through direct phosphorylation at Thr332, Thr472 and Ser552. This represents a novel mechanism of calcium-modulation of Wnt signaling and of ethanol's neurotoxicity.

Cover Image for this issue: doi: 10.1111/jnc.12539.

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