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Xiaolu Zhang, Handojo Kusumo, Amul J. Sakharkar, Subhash C. Pandey and Marina Guizzetti Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes Journal of Neurochemistry 128

Article first published online: 28 OCT 2013 | DOI: 10.1111/jnc.12465

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We propose that ethanol, by decreasing DNMT-3a (DNA methyltransferase) levels and by inhibiting DNMT activity, reduces DNA methylation of the tissue plasminogen activator (tPA) promoter and leads to increased tPA mRNA and protein expression in astrocytes; tPA released is also increased by ethanol. As tPA promotes the degradation of neuritogenic extracellular matrix, the observed dysregulation of the epigenetic mechanism of DNA methylation in astyrocytes may be involved in ethanol-induced inhibition of astrocyte-mediated neuritogenesis.

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