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Katsuro Iwase, Akinori Ishihara, Shuntaro Yoshimura, Yoshio Andoh, Masaki Kato, Naohiko Seki, Eriko Matsumoto, Takaki Hiwasa, Dominique Muller, Kohji Fukunaga and Masaki Takiguchi The secretogranin II gene is a signal integrator of glutamate and dopamine inputs Journal of Neurochemistry 128

Version of Record online: 24 OCT 2013 | DOI: 10.1111/jnc.12467

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We proposed hypothetical mechanism for the regulation of the secretogranin II gene as a signal integrator of glutamate and dopamine inputs. Glutamate or dopamine activates the Ca2+/MEK/ERK pathway, which thus contributes to the signal integration. Concurrently, activation of the PKA inhibitor KT5720-sensitive pathway by dopamine leads to accumulation of the repressor protein X that is otherwise susceptible to proteasome degradation. This repression system may determine the time window permissive to the cooperative activation by in-phase glutamate and dopamine inputs.

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