E-mail a Wiley Online Library Link

Katsuro Iwase, Akinori Ishihara, Shuntaro Yoshimura, Yoshio Andoh, Masaki Kato, Naohiko Seki, Eriko Matsumoto, Takaki Hiwasa, Dominique Muller, Kohji Fukunaga and Masaki Takiguchi The secretogranin II gene is a signal integrator of glutamate and dopamine inputs Journal of Neurochemistry 128

Version of Record online: 24 OCT 2013 | DOI: 10.1111/jnc.12467

Thumbnail image of graphical abstract

We proposed hypothetical mechanism for the regulation of the secretogranin II gene as a signal integrator of glutamate and dopamine inputs. Glutamate or dopamine activates the Ca2+/MEK/ERK pathway, which thus contributes to the signal integration. Concurrently, activation of the PKA inhibitor KT5720-sensitive pathway by dopamine leads to accumulation of the repressor protein X that is otherwise susceptible to proteasome degradation. This repression system may determine the time window permissive to the cooperative activation by in-phase glutamate and dopamine inputs.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field