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Leann H. Brennaman, Marcia L. Moss and Patricia F. Maness EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease Journal of Neurochemistry 128

Version of Record online: 20 OCT 2013 | DOI: 10.1111/jnc.12468

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PSA-NCAM and ephrinA/EphA3 coordinately regulate inhibitory synapse development. Here, we have found that ephrinA5 stimulates EphA3 kinase and ADAM10 activity to promote PSA-NCAM cleavage at a site in its second FNIII repeat, which regulates ephrinA5-induced growth cone collapse in GABAergic and non-GABAergic neurons. These findings identify a new regulatory mechanism which may contribute to inhibitory connectivity.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12514

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