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Akira Oda, Kanato Yamagata, Saya Nakagomi, Hiroshi Uejima, Pattama Wiriyasermkul, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai and Hidekazu Tanaka Nicotine induces dendritic spine remodeling in cultured hippocampal neurons Journal of Neurochemistry 128

Version of Record online: 24 OCT 2013 | DOI: 10.1111/jnc.12470

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Activation of nicotinic acetylcholine receptors (nAChRs) in brain influences plasticity and cognition. Here, activation of α4β2* nAChRs, which are expressed on glutamatergic presynaptic termini, results in the enlargement of dendritic spines through the modulation of the glutamatergic neurotransmission. The remodeled spinal architecture might be responsible for the change in responsiveness of neural circuitry, leading to cholinergic tuning of brain function.

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