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David Lutz, Gerrit Wolters-Eisfeld, Melitta Schachner and Ralf Kleene Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination Journal of Neurochemistry 128

Article first published online: 24 OCT 2013 | DOI: 10.1111/jnc.12473

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Cell adhesion molecule L1 regulates cellular responses in the developing and adult nervous system. L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment (1) which is cleaved by cathepsin E (2) yielding the L1-30 fragment that is imported to the nucleus (3), may bind to DNA and/or nuclear proteins (4), to regulate diverse cellular functions.

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