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Cecilia M. Borghese, Jessica A. Hicks, Daniel J. Lapid, James R. Trudell and R. Adron Harris GABAA receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites Journal of Neurochemistry 128

Version of Record online: 28 OCT 2013 | DOI: 10.1111/jnc.12476

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Alcohols modulate GABAA receptor function. The relative location of alcohol binding pockets in transmembrane domains was assessed by substituting critical amino acids with cysteines, and testing GABA responses and alcohol modulation before and after crosslinking double cysteine mutants and labeling single cysteine mutants. Lines show absence of crosslinking (red), and crosslinking that modified GABA responses (black) and alcohol modulation (grey).

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