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Tamara C. Hornik, Urte Neniskyte and Guy C. Brown Inflammation induces multinucleation of Microglia via PKC inhibition of cytokinesis, generating highly phagocytic multinucleated giant cells Journal of Neurochemistry 128

Version of Record online: 30 OCT 2013 | DOI: 10.1111/jnc.12477

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Inflammation resulted in the accumulation of multiple nuclei per cell in cultured microglia. This multinucleation was reversible and due to a PKC-dependent block of the last step of cell division. Multinucleate microglia were larger and had a greater capacity to phagocytose other cells, suggesting they might remove neurons in the brain.

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