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Bernard Lanz, Lijing Xin, Philippe Millet and Rolf Gruetter In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T Journal of Neurochemistry 128

Article first published online: 11 NOV 2013 | DOI: 10.1111/jnc.12479

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In this 13C-acetate labeling study, we propose a refined two-compartment analysis of brain energy metabolism based on 13C turnover curves of acetate, glutamate and glutamine measured with state of the art in vivo dynamic MRS at high magnetic field in rats, enabling a deeper understanding of the specific role of glial cells in brain oxidative metabolism. In addition, the robustness of the metabolic fluxes determination relative to MRS data quality was carefully studied.

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