Kaitlin F. Farrell, Sesha Krishnamachari, Ernesto Villanueva, Haiyan Lou, Tshianda N. M. Alerte, Eloise Peet, Robert E. Drolet and Ruth G. Perez Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function Journal of Neurochemistry 128
Aging A53T α-synuclein mice develop behaviors common to premotor Parkinson's disease (PD) with synucleinopathy occuring in adrenal gland, olfactory bulb, and intestine. Insoluble aggregated A53T α-synuclein loses PP2A-stimulatory-effects, which normally down regulate dopamine synthesis. This is the first study to link adrenal synucleinopathy to catecholamine dysregulation and anxiety. The mice are an excellent model for testing emerging neuroprotective therapies for PD.
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