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Lin Kooi Ong, Liying Guan, Hanafi Damanhuri, Ann K. Goodchild, Larisa Bobrovskaya, Phillip W. Dickson and Peter R. Dunkley Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla Journal of Neurochemistry 128

Article first published online: 30 OCT 2013 | DOI: 10.1111/jnc.12482

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We measured the basal levels of tyrosine hydroxylase phosphorylation and determined the effects of footshock stress over a 40 minute period. Footshock leads to changes in the activity of neurons in the locus coeruleus (LC) and presynaptic terminals in the medial prefrontal cortex (mPFC), as well as changes in activity of the hypothalamic-pituitary-adrenal (HPA) axis and adrenal medullary (AM) chromaffin cells.

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