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Mamoon Rashid, Naomi J. Wangler, Li Yang, Kaushik Shah, Thiruma V. Arumugam, Thomas J. Abbruscato and Vardan T. Karamyan Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain Journal of Neurochemistry 129

Version of Record online: 19 NOV 2013 | DOI: 10.1111/jnc.12513

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We provide evidence that peptidase neurolysin is up-regulated in the mouse brain membranes after stroke. Neurolysin metabolizes several neuropeptides in the brain (neurotensin, bradykinin, angiotensins I and II, substance P, hemopressin, dynorphin A(1-8), metorphamide, somatostatin), which have various functions in stroke pathophysiology. We hypothesize that neurolysin plays a key role in processes modulating the brain's response to stroke and its recovery after stroke.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12635

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