Mamoon Rashid, Naomi J. Wangler, Li Yang, Kaushik Shah, Thiruma V. Arumugam, Thomas J. Abbruscato and Vardan T. Karamyan Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain Journal of Neurochemistry 129
We provide evidence that peptidase neurolysin is up-regulated in the mouse brain membranes after stroke. Neurolysin metabolizes several neuropeptides in the brain (neurotensin, bradykinin, angiotensins I and II, substance P, hemopressin, dynorphin A(1-8), metorphamide, somatostatin), which have various functions in stroke pathophysiology. We hypothesize that neurolysin plays a key role in processes modulating the brain's response to stroke and its recovery after stroke.
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