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Anand Gururajan and Maarten van den Buuse Is the mTOR-signalling cascade disrupted in Schizophrenia? Journal of Neurochemistry 129

Article first published online: 25 DEC 2013 | DOI: 10.1111/jnc.12622

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During neurodevelopment, genetic and epigenetic factors can disrupt mTOR signalling which affects synthesis of proteins essential for correct neuronal growth and network connectivity. This renders the CNS particularly vulnerable to the effects of secondary factors during adolescence which increases the risk of developing schizophrenia in adulthood. This review discusses the functional roles of the mTOR cascade and presents evidence in support of a novel mTOR-based hypothesis of the neuropathology of schizophrenia. Testing this hypothesis will advance our understanding of the aetiology of this illness and reveal novel therapeutic targets.

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