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Yoichi Imaizumi and Hideyuki Okano Modeling human neurological disorders with induced pluripotent stem cells Journal of Neurochemistry 129

Version of Record online: 15 DEC 2013 | DOI: 10.1111/jnc.12625

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The production of human induced pluripotent stem (iPS) cells from the patients' somatic cells and their subsequent differentiation into specific cells have permitted the in vitro construction of disease models that contain patient-specific genetic information. Furthermore, innovations of gene-editing technologies on iPS cells are enabling new approaches for illuminating the pathogenic mechanisms of human diseases. In this review article, we outlined the current status of neurological diseases-specific iPS cell research and described recently obtained knowledge in the form of actual examples.

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