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Trinidad M. M. Saez, María P. Aronne, Laura Caltana and Alicia H. Brusco Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212-2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex Journal of Neurochemistry 129

Version of Record online: 6 JAN 2014 | DOI: 10.1111/jnc.12636

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During corticogenesis, the endocannabinoid system plays an important role in neural progenitor proliferation, specification, neuronal migration, and differentiation. Children prenatally exposed to marijuana have a significant impairment of higher cognitive functions. We showed in the present study that Prenatal WIN55,212-2 exposure alters radial and tangential migration and induces a delay in glutamatergic neurons differentiation in the embryonic rat cerebral cortex. The present results contribute to the knowledge on neurobiological substrates that determine neurobehavioral changes that will persist through post-natal life.

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