Jacob C. Nordman, Wiktor S. Phillips, Nathan Kodama, Sarah G. Clark, Christopher A. Del Negro and Nadine Kabbani Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth Journal of Neurochemistry 129
Stages in the development of CA3 neurons illustrate how the α7 nicotinic receptor (nAChR) can contribute to axon growth. Protein expression of α7 and G protein-regulated inducer of neurite outgrowth 1 (Gprin1) peaks between E18 and P10 in rodents. This time period is characterized by significant changes in synaptic structure and circuit development in the hippocampus. α7-mediated elevations in intracellular calcium within the growth cone (GC) are proposed to serve as ‘stop’ signal for axon growth, thereby possibly contributing to synaptic pruning. Interaction with Gprin1 ensures localization of α7 at the GC, and mediates coupling to a Gαo, GAP-43, and CDC42 signaling pathway.
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