Damian G. Zuloaga, Lance A. Johnson, Maayan Agam and Jacob Raber Sex differences in activation of the hypothalamic–pituitary–adrenal axis by methamphetamine Journal of Neurochemistry 129
Methamphetamine induces a prolonged plasma corticosterone response in females compared to males. This may be mediated by increased neural activation, involving a greater activation of glucocorticoid receptor-positive cells, in males in the CA3 and cingulate brain regions, which are involved in negative feedback functions. These findings indicate a sex difference in the neural regulation of methamphetamine-induced plasma corticosterone release.
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