G. Patrick Hussmann, Kristen E. DeDominicis, Jill R. Turner, Robert P. Yasuda, Jacquelyn Klehm, Patrick A. Forcelli, Yingxian Xiao, Janell R. Richardson, Niaz Sahibzada, Barry B. Wolfe, Jon Lindstrom, Julie A. Blendy and Kenneth J. Kellar Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain Journal of Neurochemistry 129
Article first published online: 7 FEB 2014 | DOI: 10.1111/jnc.12653
Chronic treatment with nicotine increases brain α4β2 nicotinic receptors, which may be related to nicotine addiction. When nicotine is replaced by varenicline, this receptor increase is maintained; in contrast, when nicotine is replaced by sazetidine-A the receptors return to baseline levels. The doses of drugs used here are anxiolytic and slow gain of body weight compared to saline controls.
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