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Jenhao H. Ting, David R. Marks, Stephanie S. Schleidt, Joanna N. Wu, Jacob W. Zyskind, Kathryn A. Lindl, Julie A. Blendy, R. Christopher Pierce and Kelly L. Jordan-Sciutto Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits Journal of Neurochemistry 129

Version of Record online: 12 FEB 2014 | DOI: 10.1111/jnc.12655

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E2F1 is a transcription factor regulating cell cycle progression and apoptosis. Although E2F1 dysregulation under toxic conditions can lead to neuronal death, little is known about its physiologic activity in the healthy brain. Here, we report significant age-dependent olfactory and memory deficits in mice with dysfunctional E2F1. Coincident with these behavioral changes, we also found age-matched synaptic disruption and persisting reduction in adult neurogenesis. Our study demonstrates that E2F1 contributes to physiologic brain structure and function.

Cover Image for this issue: doi: 10.1111/jnc.12561.

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