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Xiaoqun Zhang, Ze-Jun Feng and Karima Chergui GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease Journal of Neurochemistry 129

Version of Record online: 11 FEB 2014 | DOI: 10.1111/jnc.12658

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We have examined the role of NMDA receptors composed of the GluN2D subunit in the mouse striatum. These receptors inhibit the release of dopamine and of glutamate through a mechanism that involves activation of cholinergic interneurons. This inhibitory role is impaired in the dopamine-depleted striatum. This study identifies GluN2D as a potential target for therapeutic intervention in Parkinson's disease.

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