Xiaoqun Zhang, Ze-Jun Feng and Karima Chergui GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease Journal of Neurochemistry 129
We have examined the role of NMDA receptors composed of the GluN2D subunit in the mouse striatum. These receptors inhibit the release of dopamine and of glutamate through a mechanism that involves activation of cholinergic interneurons. This inhibitory role is impaired in the dopamine-depleted striatum. This study identifies GluN2D as a potential target for therapeutic intervention in Parkinson's disease.
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