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Nicole Trager, Amena Smith, Gerald Wallace IV, Mitsuyoshi Azuma, Jun Inoue, Craig Beeson, Azizul Haque and Naren L. Banik Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis Journal of Neurochemistry 130

Version of Record online: 12 FEB 2014 | DOI: 10.1111/jnc.12659

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Multiple sclerosis (MS) pathology is marked by inflammation and infiltration of myelin-specific T cells into the central nervous system. Inflammation leads to neurodegeneration in progressive MS which also leads to epitope spreading, feedback looping to more inflammation. Calpain can play a role in both arms of the disease. Here, oral dosing with SNJ-1945, a novel water-soluble calpain inhibitor, reduces experimental autoimmune encephalomyelitis clinical scores in vivo and has a two-pronged effect via anti-inflammation and protection against neurodegeneration.

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