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Cao Huang, Bo Huang, Fangfang Bi, Linda H. Yan, Jianbin Tong, Jufang Huang, Xu-Gang Xia and Hongxia Zhou Profiling the genes affected by pathogenic TDP-43 in astrocytes Journal of Neurochemistry 129

Version of Record online: 9 FEB 2014 | DOI: 10.1111/jnc.12660

Thumbnail image of graphical abstract

Restricted expression of pathogenic TDP-43 in astrocytes causes non-cell-autonomous motor neuron death in transgenic rats. As revealed by microarray assay, pathogenic TDP-43 in astrocytes preferentially altered expression of the genes encoding secretory proteins. Whereas neurotrophic genes were down-regulated, neurotoxic genes were up-regulated. Therefore, TDP-43 pathogenesis is associated with simultaneous induction of neurotoxic genes and repression of neurotrophic genes in astrocytes.

Cover Image for this issue: doi: 10.1111/jnc.12564.

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