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Ye Jin, Koichi Sato, Ayaka Tobo, Chihiro Mogi, Masayuki Tobo, Naoya Murata, Satoshi Ishii, Dong-Soon Im and Fumikazu Okajima Inhibition of interleukin-1β production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia Journal of Neurochemistry 129

Version of Record online: 10 FEB 2014 | DOI: 10.1111/jnc.12661

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A number of studies have shown that extracellular acidification in brain is observed in ischemia and neurodegenerative disorders. However, the molecular mechanism by which extracellular acidification regulates the biological activities of microglia remains uncharacterized. Here, we examined the extracellular acidic pH regulation of IL-1β production, especially focusing on TDAG8, a member of OGR1 family receptors. Our results suggest that extracellular acidic pH inhibited lipopolysaccharide -induced IL-1β production at least partly through the TDAG8/cAMP pathway, by inhibiting ERK and JNK activities.

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