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Pedro Cisternas, Carmen Silva-Alvarez, Fernando Martínez, Emilio Fernandez, Luciano Ferrada, Karina Oyarce, Katterine Salazar, Juan P. Bolaños and Francisco Nualart The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism Journal of Neurochemistry 129

Version of Record online: 19 FEB 2014 | DOI: 10.1111/jnc.12663

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We proposed that the ascorbic acid (AA) taken up by neurons is rapidly oxidized to dehydroascorbic acid (DHA), which inhibits glycolysis and activates the pentose phosphate pathway (PPP), consequently producing NADPH, a critical antioxidant in the recycling of oxidized glutathione (GSSG). In these metabolic conditions, neurons increase lactate uptake, probably using it as an energy source. This data supported the idea that DHA could play a critical role in the modulation of energy metabolism in neurons.

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