E-mail a Wiley Online Library Link

Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomitsu Iida, Ryuichi Harada, Attayeb S. Mohsen, Yamato Miura and Kazuhiko Yanai Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line Journal of Neurochemistry 129

Version of Record online: 13 FEB 2014 | DOI: 10.1111/jnc.12665

Thumbnail image of graphical abstract

Monoamine neurotransmitters should be immediately removed from the synaptic cleft to avoid excessive neuronal activity. Recent studies have shown that astrocytes and neurons are involved in monoamine removal. We aimed to elucidate the transporters responsible for monoamine transport by astrocytes in 1321N1, a human astrocytoma-derived cell line. Kinetics analysis suggested the involvement of low-affinity monoamine transporters, e.g., organic cation transporter (OCT) 2 and 3 and plasma membrane monoamine transporter (PMAT). Our results indicate that PMAT and OCT3 in human astrocytes are involved in monoamine clearance.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field