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Michael Haas, Ahmed Shaaban and Georg Reiser Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor Journal of Neurochemistry 129

Version of Record online: 13 FEB 2014 | DOI: 10.1111/jnc.12666

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The human P2Y11 nucleotide receptor plays key role in immune-responses in brain and other tissues. We provide evidence for significant functional disturbance of the P2Y11 receptor carrying the Alanine-87-Threonine mutation caused by natural polymorphism. This receptor defect is apparent only when co-expressed with P2Y1 receptors. We found reductions in ligand-induced calcium and cAMP responses and in nucleotide-induced receptor internalization / resensitization. Thus, prolonged nucleotide treatments are the basis for the molecular defects of the mutant receptor in diseases.

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