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Malte F. Alf, João M. N. Duarte, Hongxia Lei, Stefanie D. Krämer, Vladimir Mlynarik, Roger Schibli and Rolf Gruetter MRS glucose mapping and PET joining forces: re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia Journal of Neurochemistry 129

Article first published online: 19 FEB 2014 | DOI: 10.1111/jnc.12667

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The lumped constant (LC) is a correction factor employed to estimate the glucose metabolic rate (CMRglc) from the metabolic rate of a radioactive glucose analog such as 18F-fluorodeoxyglucose (FDG). By combining FDG positron emission tomography (PET) with magnetic resonance spectroscopic imaging (MRSI) of glucose dynamics, we determined the FDG LC in the rat brain under isoflurane anaesthesia.

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