E-mail a Wiley Online Library Link

Martin Kuss, Eleni Adamopoulou and Philipp J. Kahle Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages Journal of Neurochemistry 129

Article first published online: 24 FEB 2014 | DOI: 10.1111/jnc.12668

Thumbnail image of graphical abstract

Leucine-rich repeat kinase 2 (LRRK2) is a major risk factor for the development of Parkinson's disease (PD). However, the role of LRRK2 in the affected neurons remains enigmatic. Recently, LRRK2 has been reported to be strongly expressed in the immune system. Here, we demonstrate that LRRK2 is induced by Interferon gamma via extracellular signal-regulated kinase 5 (ERK5) in macrophages, thus providing new insights in LRRK2 and ERK5 biology.

Read the Editorial Highlight for this article on page 895.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.