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Anjani K. Tiwari, Joji Yui, Masayuki Fujinaga, Katsushi Kumata, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Akiko Hatori, Jun Maeda, Nobuki Nengaki and Ming-Rong Zhang Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammation in the brain Journal of Neurochemistry 129

Version of Record online: 24 FEB 2014 | DOI: 10.1111/jnc.12670

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We developed 2-[5-(4-[11C]methoxyphenyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-phenylacetamide ([11C]MBMP) as a novel positron emission tomography ligand for imaging of translocator protein (18 kDa, TSPO) in the brain. [11C]MBMP exhibited high in vitro and in vivo specific binding with TSPO in the ischemic rat brain.

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