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Wei Shen, Anastasia G. Henry, Katrina L. Paumier, Li Li, Kewa Mou, John Dunlop, Zdenek Berger and Warren D. Hirst Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons Journal of Neurochemistry 129

Article first published online: 3 MAR 2014 | DOI: 10.1111/jnc.12672

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Inhibition of GlcCer synthase enhances autophagy by inhibiting AKT-mTOR signaling, and increases the number and size of lysosomal/late endosomal structures. Furthermore, inhibition of GlcCer synthase decreased levels of mutant α-synuclein in neurons, which may represent a potential therapeutic target for Parkinson's disease.

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