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Mélanie Craveiro, Virginie Clément-Schatlo, Denis Marino, Rolf Gruetter and Cristina Cudalbu In vivo brain macromolecule signals in healthy and glioblastoma mouse models: 1H magnetic resonance spectroscopy, post-processing and metabolite quantification at 14.1 T Journal of Neurochemistry 129

Article first published online: 26 FEB 2014 | DOI: 10.1111/jnc.12673

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In 1H magnetic resonance spectroscopy, the precise knowledge of the macromolecule signals is essential. After introducing a novel method for a flexible and robust post-processing of measured macromolecule signals, the absence of significant differences in metabolite quantification as a result of regional macromolecule variability was demonstrated in the mouse brain while several alterations of the macromolecule spectrum were observed in a mouse model of human glioma.

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