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Michelle Muller and Blair R. Leavitt Iron dysregulation in Huntington's disease Journal of Neurochemistry 130

Version of Record online: 28 MAY 2014 | DOI: 10.1111/jnc.12739

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Huntington's disease (HD) is one of many neurodegenerative diseases reported to have alterations in brain iron homeostasis. Whether elevated brain iron occurs in HD, and whether elevated iron levels play a significant contributory role in HD pathogenesis remains currently unclear. In this review, we discuss potential mechanisms by which mutant huntingtin-mediated increases in intracellular calcium and elevated intracellular iron may interact to result in elevated levels of reactive oxygen species leading to lipid peroxidation, DNA damage, and neuronal cell death.

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