Thomas Clairembault, Willem Kamphuis, Laurène Leclair-Visonneau, Malvyne Rolli-Derkinderen, Emmanuel Coron, Michel Neunlist, Elly M. Hol and Pascal Derkinderen Enteric GFAP expression and phosphorylation in Parkinson's disease Journal of Neurochemistry 130
We showed that GFAP is over-expressed and hypophosphorylated in the enteric glial cells (EGCs) of Parkinson's disease (PD) patients as compared to healthy subjects and patients with atypical parkinsonism (MSA, multiple system atrophy and PSP, progressive supranuclear palsy). Our findings provide evidence that enteric glial reaction occurs in PD but not in PSP and MSA and further reinforce the role of the enteric nervous system in the pathophysiology of PD.
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