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Graciela L. Mazzone and Andrea Nistri S100β as an early biomarker of excitotoxic damage in spinal cord organotypic cultures Journal of Neurochemistry 130

Version of Record online: 19 MAY 2014 | DOI: 10.1111/jnc.12748

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Excitotoxicity is a major mechanism responsible for neuronal death following acute spinal cord injury. The calcium-binding protein S100β is released by astrocytes into the extracellular compartment during the first 24 h after the initial insult and represents a useful biomarker of lesion progression as its level is related to the occurrence and severity of neuronal loss.

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