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Xiaojuan He, Masato Ishizeki, Naoki Mita, Seitaro Wada, Yoshifumi Araki, Hiroo Ogura, Manabu Abe, Maya Yamazaki, Kenji Sakimura, Katsuhiko Mikoshiba, Takafumi Inoue and Toshio Ohshima Cdk5/p35 is required for motor coordination and cerebellar plasticity Journal of Neurochemistry 131

Version of Record online: 28 MAY 2014 | DOI: 10.1111/jnc.12756

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Purkinje cells play an important role in motor learning, the underlying mechanisms of which have been studied during the last two decades. We report here that the ablation of Cdk5/p35 in Purkinje cells impairs motor coordination, along with deficits in the cerebellar synaptic plasticity, which gives new insights into the mechanism of synaptic plasticity in Purkinje cells.

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Cover Image for this issue: doi: 10.1111/jnc.12587.

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